Recombinant canine herpesviruses

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof


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4241471, 4241861, 4352351, 435 691, 435 693, 5303883, 530395, 530350, 536 232, 536 2372, A61K 39245, C12N 701, C07K 100, C12P 2102




The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.

patent: 5223424 (1993-06-01), Cochran et al.
patent: 5266489 (1993-11-01), Rey-Senelonge et al.
patent: 5310668 (1994-05-01), Ellis et al.
patent: 5324664 (1994-06-01), Nunberg et al.
Limcumpao et al., J Vet Med Sci, 53(3), 1991, p. 423-432.
Xuan et al., Arch Virol, 122(3-4), 1992, p. 359-365.
Limbach et al., J Gen Virol, 75(8), 1994, p. 2029-2039.
Xuan et al., Japan J Vet Sci, 52(50, 1990, p. 899-905.
Binn, et al., "Viruses Recovered from Laboratory Dogs with Respiratory Disease," pp. 140-145, P.S.E.B.M., (rec'd May 17, 1967) v. 126.
Breeden, et al., "Identification and Transcriptional Mapping of Genes Encoded at the IR/Us Junction of Equine Herpesvirus Type 1," pp. 649-660, Virology, 191 (1992).
Carmichael, "Herpesvirus canis: Aspects of Pathogenesis and Immune Response," pp. 1714-1721, J.A.V.M.A., vol. 156 (Jun. 15, 1970).
de Wind, et al., "Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity," pp. 351-359, Journal of General Virology, 74 (1993).
Elton, et al., "Sequence analysis of the 4.7-kb BamHI-EcoRI fragment of the equine herpesvirus type-1 short unique region," pp. 203-208, Elsevier Science Publishers B.V. 0378-1119/91 (1991).
Graham, et al., "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA," pp. 456-467, Virology, 52 (1973).
Holliday, et al., "Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine," pp. 197-203, Antiviral Research, 16 (1991).
Kit, et al., "Nucleotide Sequence Changes in Thymidine Kinase Gene of Herpes Simplex Virus Type 2 Clones from an Isolate of a Patient Treated with Acyclovir," pp. 1483-1490, Antimicrobial Agents and Chemotherapy, vol. 31, No. 10 (Oct. 1987).
Kit, et al., "Thymidine Kinase (TK) Induction after Infection of TK-Deficient Rabbit Cell Mutants with Bovine Herpesvirus Type 1 (BHV-1): Isolation of TK .sup.- BHV-1 Mutants" pp. 381-389, Virology, 130 (1983).
Lees, et al., "The Epstein-Barr Virus Candidate Vaccine Antigen gp340/220 is Highly Conserved between Virus Types A and B," pp. 578-586, Virology, 195 (1993).
Liang, et al., "Identification and Deletion Mutagenesis of the Bovine Herpesvirus 1 dUTPase Gene and a Gene Homologous to Herpes Simplex Virus UL49.5," pp. 42-50, Virology, 195 (1993).
Limbach, et al., "Nucleotide sequence of the genes encoding the canine herpesvirus gB, gC and gC homologues," pp. 2029-2039, Journal of General Virology, 75 (1994).
McGeoch, et al., The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1, pp. 1531-1574, Journal of General Virology, 69 (1988).
McGeoch, et al., "Sequence Determination and Genetic Content of the Short Unique Region in the Genome of Herpes Simplex Virus Type 1," pp. 1-13, 1985 Academic Press Inc. (London) Ltd. (received Jul. 30, 1984).
Meignier, et al., "Virulence of and Establishment of Latency by Genetically Engineered Deletion Mutants of Herpes Simplex Virus 1," pp. 251-254, Virology, 162 (1988).
Meinkoth, et al., "Hybridization of Nucleic Acids Immobilized on Solid Supports," pp. 267-284, Analytical Biochemistry, 138 (1984).
Nunberg, et al., "Identification of the Thymidine Kinase Gene of Feline Herpesvirus: Use of Degenerate Oligonucleotides in the Polymerase Chain Reaction to Isolate Herpesvirus Gene Homologs," pp. 3240-3249, Journal of Virology, vol. 63, No. 8 (Aug. 1989).
Peterson, et al., "Propagation and Quantitation of Animal Herpesviruses in Eight Cell Culture Systems," pp. 93-98, Comp. Immun. Microbiol. Infect. Dis., vol. 11, No. 2 (1988).
Remond, et al., "Gene organization in the U.sub.L region and inverted repeats of the canine herpesvirus genome," pp. 37-48, Journal of General Virology, 77 (1996).
Remond, et al., "Sequence of the canine herpesvirus thymidine kinase gene: taxon-preferred amino acid residues in the alphaherpesviral thymidine kinases," pp. 341-354, Virus Research, 39 (1995).
Riggio, et al., "DNA sequence of a gene cluster in the equine herpesvirus-4 genome which contains a newly identified herpesvirus gene encoding a membrane protein," pp. 171-178, Archives of Virology, 133 (1993).
Robertson, et al., Evolution of the herpes thymidine kinase: identification and comparison of the equine herpesvirus 1 thymidine kinase gene reveals similarity to a cell-encoded thymidylate kinase, pp. 11303-11317, Nucleic Acids Research, vol. 16, No. 23 (1988).
Simard, et al., "Sequencing and 5'- and 3'-end Transcript Mapping of the Gene Encoding the Small Subunit of Ribonucleotide Reductase from Bovine Herpesvirus Type-1," pp. 689-701, Virology, 190 (1992).
Spatz, et al., "Identification of the feline herpesvirus type 1 (FHV-1) genes encoding glycoproteins G, D, I and E: expression of FHV-1 glycoprotein D in vaccinia and raccoon poxviruses," pp. 1235-1244, Journal of General Virology, 75 (1994).
Tack, et al., The Complete DNA Sequence and the Genetic Organization of the Short Unique Region (U.sub.s) of the Bovine Herpesvirus Type 1 (ST Strain), pp. 409-421, Virology, 199 (1994).
Telford, et al., "The DNA Sequence of Equine Herpesvirus-1," pp. 304, 316, Virology, 18 (1992).
van Zijl, et al., "Regeneration of Herpesviruses from Molecularly Cloned Subgenomic Fragments," pp. 2191-2195, Journal of Virology, vol. 61, No. 6 (Jun. 1988).
Walboomers, et al., "A New Method for the Isolation of Herpes Simplex Virus Type 2 DNA," pp. 256-258, Virology, 74 (1976).
Wolff, et al., "Detect Gene Transfer into Mouse Muscle in Vivo," pp. 1465-1468, Science, vol. 247 (Mar. 23, 1990).
Pyles, et al., 1994, J. Virol., vol. 68(7), pp. 4514-4524.
Feng, et al., 1985, J. Mol. Evol. 21, pp. 112-125.
Haanes, et al., Virus Research, vol. 53, pp. 151-162, 1998.
Johnson, et al., 1993, J. Mol. Biol. 233, pp. 716-738.
Shulze, et al., Vet Pathol, vol. 35, pp. 209-217, 1998.
Smith, K.C., The Veterinary Journal, vol. 153, pp. 253-268, 1997.
Tyack, et al., 1997, DNA Sequence--The Journal of Sequencing and Mapping, vol. 7(6), pp. 365-368.


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