Rab protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 4352523, 435 6, 536 231, 536 235, 536 2432, C12N 1500

Patent

active

058437177

ABSTRACT:
The present invention provides a human novel RAB protein (SRAB) and polynucleotides which identify and encode SRAB. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of SRAB.

REFERENCES:
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Waner et al. (1996) Accession No. U18771, GenBank database.
Saxe et al. (1990) Mol. Cell. Biol., vol. 10, No. 5, pp. 2367-2378.
Saxe et al. (1990) Accession No. B34716, B61571, GenBank database.
Reeck et al. (1987) Cell, vol. 50, p. 667.
Novick, P., et al., "Friends and Family: The Role of the Rab GTPases in Vesicular Traffic", Cell, 75: 597-601 (1993).
Khosravi-Far, R., et al., "Isoprenoid modification of rab proteins terminating in CC or CXC motifs", Proc. Natl. Acad. Sci. USA, 88: 6264-6268 (1991).
Wagner, A.C.C., et al., "Molecular cloning of a new member of the rab protein family, rab 26, from rat pancreas", Biochemical and Biophysical Research Communications, 207 (3): 950-956 (1995).
Matteoli, M., et al., "Association of Rab 3A with Synaptic Vesicles at Late Stages of the Secretory Pathway", The Journal of Cell Biology, 115: 625-633 (1991).
Fridell, R., et al., "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway", Proc. Natl. Acad. Sci. USA, 39: 4421-4424 (1996).
Seabra, M.C., et al., "Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase", Science, 259: 377-381 (1993).
Tuomikoski, t., ET AL., "Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2", Nature, 342: 942-945 (1989).
Nimmo, E.R., et al., "The MEL gene: a new member of the RAB/YPT class of RAS-related genes", Oncogene, 6 (8): 1347-1351 (1991).
Mindong, R., et al, "In its active form, the GTP-binding protein rab8 interacts with a stress-activated kinase", Proc. Natl. Acad. Sci. USA, 93: 5151-5155 (1996).
Wagner, A.C., et al., (GI 619734) GenBank Sequence Database (Accession U18771), National Center for Biotechnology Informatiion: National Library of Medicine, Bethesda, Maryland 2084 (1995).
Wagner, A.C., et al., (GI 619733) GenBank Sequence Database (Accession U18771), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1995).
Nimmo, E.R., et al., (GI 234746) GenBank Sequence Database (Accession S53268), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1992).
Nimmo, E.R., et al., (GI 234745) GenBank Sequence Database (Accession S53268), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1992).

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