Process for the preparation of ibuprofen

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435141, 435196, 435280, 4352521, 4352525, 435823, 435882, C12P 700, C12N 900

Patent

active

051089173

ABSTRACT:
A process is provided for the preparation of ibuprofen enriched in R isomer, which comprises subjecting an ester of ibuprofen, to the action of a micro-organism or substances derived thereof, that will stereoselectively hydrolyse the ester to form ibuprofen predominantly having R configuration.

REFERENCES:
patent: 4886750 (1989-12-01), Bertola et al.
"Asymmetric Hydrolysis of (.+-.)-alpha-substituted Carboxylic Acid Esters with Microorganism," Agricultural and Biological Chemistry, vol. 45, No. 6, (1981) pp. 1389-1392.
Bergey's Manual of Systematic Bacteriology, vols. 1 & 2, ed. Krieg, pp. 269-271 (vol. 1), pp. 1015-1019 and 1131 (vol. 2).

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