Process for the preparation of a pharmaceutically active compoun

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435141, 435280, 435822, 435830, 435836, 435839, 435849, 435874, 435886, C12P 4100, C12P 1700, C12N 120, C12N 918

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048867500

ABSTRACT:
A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula ##STR2## wherein R.sub.1 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof.

REFERENCES:
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patent: 4601987 (1986-07-01), Klibanov et al.
patent: 4762793 (1988-08-01), Cesti et al.
Agricultural & Biological Chem., vol. 45, No. 6, Jun. 1981, 1389-1392.
Chem Abstracts, vol. 85, 8/16/76, p. 31.
Microbiology Abstracts, vol. 11, No. 9, 9/76, Abstract No. 11A6024, 1 page.
Tetrahedron Letters, vol. 27, No. 16, pp. 1763-1766.
Gene, vol. 35, 1985, pp. 272-279, H. Ounissi et al.

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