Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
C424S484000, C530S333000, C530S339000, C530S350000
A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found inPyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly™.
patent: 5629020 (1997-05-01), Leone-Bay et al.
patent: 5712366 (1998-01-01), McGrath et al.
patent: 5851536 (1998-12-01), Yager et al.
patent: 5955343 (1999-09-01), Holmes et al.
patent: 6048736 (2000-04-01), Kosak
patent: 6083902 (2000-07-01), Cederhom-Williams
patent: WO-00/40962 (2000-07-01), None
Jenekhe, S. et al Abstracts of Papers—American Chemical Society (2000), 220th, PMSE-268.
Urry, D. et al. Materials Research Society Symposium Proceedings (1992), 255(Hierarchically Structured Materials), 411-22.
Gyorog D.A. AIAA meeting, Jan. 19-21, New York, 1970.
Stetter, “Ultrathin mycelia-forming organisms fro submarine volcanic areas having an optimum growth temperature of 105° C.”,Lehrstuhl für Mikrobiologie, Universität Regensburg, Oct. 1, 1982.
Stetter et al., “Pyrodictium gen. nov., a New Genus of Submarine Disc-shaped Sulphur Reducing Archaebaceteria Growing Optimally at 105° C.”,Systemiatic and Applied Microbiology, vol. 4, Aug. 8, 1983, pp. 535-551.
Konig et al., “The fine structure of the fibers ofOyrodictium occultum”,Federation of European Microbiological Societies, 1988, pp. 207-212.
Rieger et al., “Ultrastucture of the hYperthermophilic ArchaeonPyrodictium abyssi”, Lehrstuhl für Mikrobiologie, May 18, 1995, pp. 78-87.
Riegger et al., “Cultivation of Hyperthermophilic archaea in capillary tubes resulting in improved preservation of fine structures”,Arch Microbiol, (1997) 268:373-379.
Pley et al., “Pyrodictium abyssisp., nov. Represents a Novel Heterotrophic Marine Archaeal Hyperthermophile Growing at 110° C.”,System Appl. Microbiol., 14, 245-253 (1991).
Mai, Bianca, “In Vitro Untersuchungen zum extrazellulären Netzwerk vonPyrodictium abyssiTAG11”Biologie und Medizin, University of Regensburg, Naturwissenschaftlichen Fakultat III 1998 with English translation.
Mai et al., Journal of Bacteriology (1998) 180:4030-4035.
Mai, Genetic Characterization and Expression of the Large Thermosome Subunit fromPyrodictium occultuminE. coliand Molecular Biological Studies on the Extracellular Network fromPyrodictium abyssiIsolate TAG11. Thesis for the Department of Microbiology at the University of Regensburg (1995).
Rieger, Electron Microscope and Biochemical Studies on the Construction of the Network inPyrodictium. Dissertation for the Department of Microbiology at the University of Regensburg (1998).
Schneider, Electron Microscope and Protein Chemical Studies on the Structure of the Fibers and the S-Layers fromPyrodictium occultum. Thesis for the Department of Microbiology at the University of Regensburg (1993).
Supplementary Partial European Search Report mailed on Sep. 6, 2005, for EP Patent Application No. 01996025.1, filed on Nov. 30, 2001, 4 pages.
Lafferty W. Michael
Mathur Eric J.
Morrison & Foerster / LLP
Method of making a protein polymer and uses of the polymer does not yet have a rating. At this time, there are no reviews or comments for this patent.If you have personal experience with Method of making a protein polymer and uses of the polymer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of making a protein polymer and uses of the polymer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4037194