Jun kinase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0


C514S299000, C514S300000, C514S393000, C546S118000, C546S121000

Reexamination Certificate



The present invention provides novel compounds of formula Iand their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.

patent: 4719218 (1988-01-01), Bender et al.
patent: 0 737 685 (1996-10-01), None
patent: 1 106 621 (2001-06-01), None
patent: WO 92/10498 (1992-06-01), None
patent: WO 92/10499 (1992-06-01), None
patent: WO 99/21859 (1999-05-01), None
patent: WO 00/35909 (2000-06-01), None
patent: WO 00/35921 (2000-06-01), None
patent: WO 00/56710 (2000-09-01), None
patent: WO 01/12609 (2001-02-01), None
patent: WO 01/47922 (2001-07-01), None
patent: WO 01/49288 (2001-07-01), None
patent: WO 02/16359 (2002-02-01), None
patent: WO 02/081475 (2002-10-01), None
patent: WO 03/082869 (2003-10-01), None
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Ham et al, Neuron, 14(5):927-939 (1995).
Watson et al, J. Neurosci., 18(2):751-762 (1998).
Eilers et al, J. Neurosci., 18(5):1713-1724 (1998).
Eilers et al, J. Neurochem., 76(5):1439-1454 (2001).
Young et al, J. Biol. Chem., 272(18):12116-12121 (1997).
Lisnock et al, Biochemistry, 39(11):3141-3148 (2000).
Cao et al, J. Biol. Chem., 279(34):35903-35913 (2004).
Henry et al , Bioorg. Med. Chem. Lett. 1998, 8, 3335-3340.
Adams et al. , Bioorg. Med. Chem. Lett. 2001, 11, 2867-2870.
Harper and LoGasso,Drugs of the Future2001, 26, 957-973.


Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.


Jun kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Jun kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Jun kinase inhibitors will most certainly appreciate the feedback.

Rate now


Profile ID: LFUS-PAI-O-3915307

All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.