Intermediate conductance calcium-activated potassium...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate



This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux though a calcium-activated potassium channel.

patent: 6277978 (2001-08-01), Keating et al.
patent: 0 614 977 (1994-03-01), None
patent: WO 890979 (1989-10-01), None
patent: WO 9521252 (1995-08-01), None
patent: WO 9903882 (1999-01-01), None
patent: WO 99 03889 (1999-01-01), None
patent: WO 9903889 (1999-01-01), None
patent: WO 9925347 (1999-05-01), None
DATABASE EMBL 'Online!, Oct. 4, 1996 Database accession No. U69883, XP002212554, the whole document.
DATABASE EMBL 'Online!, Oct. 4, 1996 Database accession No. U69884, XP002212555, the whole document.
DATABASE EMBL. 'Online!, Oct. 4, 1996 Database accession No. U69882, XP002212556, the whole document.
Database Swissprot 'Online!, Nov. 1, 1996, Database accession No. Q19186, XP002212558, the whole document.
McCobb D P et al.: “A Human Calcium-Activated Potassium Channel Gene Expressed in Vascular Smooth Muscle”, American Journal of Physiology: Heart and Circulatory Physiology, The American Physiological Society, XX, vol. 269, NR. 3, Page(s) H767-H777 XP002924141, ISSN: 0363-6135.
Kohler M et al.: “Small-conductance, calcium-activated potassium channels from mammalian brain see comments!”, Science, American Association for the Advancement of Science, US, vol. 283,NR. 5282, Page(s) 1709-1714 XP002091031, ISSN 0038-8075 (1996).
Kohler et al., Small-Conductance, Calcium-Activated Potassium Channels for Mammalian Brian,Science, 273:1709-1714 (Sep. 1996).


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