DNA encoding ATP-sensitive potassium channel genes

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives


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536 235, C07H 2102, C07H 2104




This invention relates to DNA and protein compositions useful in the diagnosis and treatment of diabetes, heart disease and skeletal muscle disease. More specifically, this invention relates to DNA and protein compositions for ATP-sensitive potassium channel proteins, and methods of using these compositions.

patent: 5356775 (1994-10-01), Hebert et al.
Cook, Daniel L., et al. (1984) "Intracellular ATP directly blocks K.sup.+ channels in pancreatic B-cells", Nature 311:271-273.
Ashcroft, Frances M., et al. (1984) "Glucose induces closure of single potassium channels in isolated rat pancreatic .beta.-cells", Nature 312:446-448.
Misler, Stanley, et al. (1986) "A metabolite-regulated potassium channel in rat pancreatic B cells", Proc. Natl. Acad. Sci. 83:7119-7123.
Ashcroft, Frances M. (1988) "Adenosine 5'-Triphosphate-Sensitive Potassium Channels", Ann. Rev. Neurosci. 11:97-118.
Standen, Nicholas Bo, et al. (1989) "Hyperpolarizing Vasodialators Activate ATP-Sensitive K.sup.+ in Artenal Smooth Muscle", Science 245:177-180.
Quast, Ulrich, et al. (1989) "Moving together: K+ channel openers and ATP-sensitive K+ channels", TiPS 10:431-435.
Ashford, Michael L.J., et al. (1990) "Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels", European Journal of Physiology 415:479-483.
Fan, Zheng, et al. (1990) "Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes", European Journal of Physiology 415:387-394.
Daut, Jurgen, et al. (1990) "Hypoxic Dilation of Coronary Arteries is Mediated by ATP-Sensitive Potassium Channels", Science 247:1341-1344.
Kirsch, G.E., et al. (1990) "Coupling of ATP-sensitive K+ channels to A.sub.1 receptors by G proteins in rat ventricular myocytes", American Physiology Society H820-H826.
Nichols, C.G. et al. (1991) "Adenosine triphosphate-sensitive potassium channels in the cardiovascular system", Invited Review H1675-H1686.
Janigro, Damir, et al. (1993) "ATP-sensitive K+ channels in rat aorta and brain microvascular endothelial cells", American Physiological Society C812-C821.
Edwards, Gillian, et al. (1993) "The Pharmacology of ATP-Sensitive Potassium Channels", Annu. Rev. Pharmacol. Toxicol. 33:597-637.


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