Dietary and hormonal regulation of expression of exogenous genes

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses


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514 44, 800 2, 800DIG2, 935 62, 935111, C12N 1500, A61K 4800




A transgenic animal is constructed in which one or more cells contain a promoter to the gene for cytosolic PEPCK operably linked to a non-PEPCK gene of interest. Expression of this gene is controlled by modifying the protein and carbohydrate components of the animal's diet, or by direct hormonal regulation. The PEPCK promoter is induced by high protein and inhibited by high carbohydrate, or more directly by cAMP and insulin. The linked gene is expressed essentially only after bith and essentially only in particular tissues. The PEPCK promoter has a extremely high promoter strength.

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