[Des-gly].sup.10 -GnRH nonapeptide anide analogs in position 6 h

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07C10352, C08H 100

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active

040050637

ABSTRACT:
An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating lutenizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5-100 .mu.g./kg.

REFERENCES:
patent: 3914412 (1975-10-01), Gendrich et al.
Fujino et al., Biochem. Biophys. Res. Comm., 57, 1248-1256 (1974).
Martinez et al., Biochem. Biophys. Res. Comm., 59, 1226-1232 (1974).

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