Colony-stimulating factor derivatives

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 695, 435 9132, 4351723, 43525421, 536 235, 530350, C12P 2102

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active

055455360

ABSTRACT:
Novel proteins possessing substantially the same biological activity as human GM-CSF, as well as proteins having a higher specific activity than native human GM-CSF, are disclosed. The proteins may (a) be unglycosylated; (b) lack N-linked glycosylation but have O-linked glycosylation; or (c) lack one of the two N-linked carbohydrate chains characteristic of native human GM-CSF. The proteins are produced using recombinant DNA techniques in eucaryotic host cells, such as mammalian, yeast, and filamentous fungal host cells. Pharmaceutical compositions including an effective amount of one of the proteins of the invention and a physiologically acceptable carrier or diluent are also disclosed.

REFERENCES:
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Davis et al in Microbiology 2nd Edition, Harper & Row Publishers, Hegerstown, MD (1973) pp. 966-977.
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Woang et al Science vol. 228 pp. 810-815 (1985).
De Lamarter et al EMBO vol. 4 pp. 2575-2581.
Miyajima et al EMBO vol. 5 pp. 1193-1197 (1986).
Leatherborrow et al Protein Engineering vol. 1 pp. 7-16 (1986).

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