Calcitonin analogue and use thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Calcitonin; related peptides

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514808, 514 12, A61K 3823, C07K 14585

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active

055368123

ABSTRACT:
The invention provides a polypeptide of calcitonin analogue and use thereof. The polypeptide has such an amino acid sequence that proline-amide residue (Pro-NH.sub.2) at C-terminal of native eel calcitonin is substituted to a homoserine amide residue (Hse.multidot.NH.sub.2).

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"Synthesis and Biological Activity of Peptide Sequences Related to Porcine .alpha.Thyrocalcitonin," Chemistry and Immunochemistry, P. Sieber et al., pp. 28-33 (1968).
"Structure-Activity Relationship of Human Calcitonin. III. Biological Activity of Synthetic Analogues with Shortened or Terminally Modified Peptide Chains," Experientia, vol. 32, pp. 246-249 (1976), W. Rittel et al.
"Thyrocalcitonin: Hypocalcemic Hypophosphatemic Principle of the ThyroidGland," Science vol. 146, pp. 412-413 (1963), P. F. Hirsch et al.
"Calcitonin: Inhibitory Effect on Eating in Rats," Science vol. 206, pp. 850-852 (1979), W. J. Freed et al.
"Inhibition of Gastric Secretion by Calcitonin in Man," Horm. Metab. Res., vol. 3, p. 140 (1971), R. D. Hesch et al.
"Peptides From The Calcitonin Genes: Molecular Genetics, Structure & Function," Journal on Biochem., vol. 255, p. 377-390 (1988), L. H. Breimer et al.

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