C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)-

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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C07C27100

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056841752

ABSTRACT:
The synthesis of paclitaxel obtained from the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side chain acid, thereby producing an intermediate which may be acylated and deprotected to produce paclitaxel.

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"Enantio-and Stereo-selective Route to the Taxol Side Chain via Asymmetric Epoxidation of trans-Cinnamyl Alcohol and Subsequent Epoxide Ring Opening", Bonini et al, J. Chem. Soc., Chem. Commun., pp. 2767-2768, 1994.
"Highly Sterocontrolled and Efficient Preparation fo the Protected, Esterfication--Ready Docetaxel ( Taxotere) Side Chain", Kanazawa et al, J. Org. Chem., vol. 59, No. 6, pp. 1238-1240, 1994.
"Aminohydroxylation--Catalytic Asymmetric Reaction Achieved", Chemical and Engineering News, pp. 6-7, Feb. 19, 1996.

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