Antineoplastic agent-entrapping liposomes

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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Details

4284022, A61K 3722, A61J 500, B01J 1302, B32B 516

Patent

active

049064770

ABSTRACT:
Some of antineoplastic agents, for instance, adriamycin and daunorubicin, have a positive charge at physiological pH. Such drugs possess high affinity for binding to steroidal sulfate by means of electrostatic force. The invention utilizes this property to prepare steroidal sulfate liposomes having a net negative charge and encapsulating the antineoplastic agent.

REFERENCES:
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4605630 (1986-08-01), Kung et al.
patent: 4745074 (1988-05-01), Schreier et al.
patent: 4746516 (1988-05-01), Moro et al.
patent: 4756910 (1988-07-01), Yagi et al.
patent: 4766046 (1988-08-01), Abra et al.
patent: 4780455 (1988-10-01), Lieberman et al.
patent: 4822777 (1989-04-01), Abra
patent: 4828837 (1989-05-01), Uster et al.
Gabizon A. et al., "Liposome Formulations With Prolonged Circulation Time", Proc. Natl. Acad. Sci. USA, vol. 85, pp, 6949-6953, (1988).
Kurono et al., Chem Abs., vol. 110, No. 18, "Antineoplastic Agent-Entrapping Liposomes", abs. #160396b.
Cullis et al., "Liposomes as Pharmaceuticals", in Liposomes From Biophysics to Therapeutics, Astro ed., Marcel Dekker, 1987, pp. 53-65.

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