Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
4242561, 536 237, A01N 4304
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
patent: 5962430 (1999-10-01), Loosmooore et al.
patent: 5981503 (1999-11-01), Loosmoore et al.
patent: 6025342 (2000-02-01), Loosmoore et al.
Zangwill et al, 1993 MMWR 42:1-15.
Schoendorf et al, 1994 Pediatrics 93:663-8.
Brenner S., 1988 Nature 334:528-530.
O'Hagan 1992 Clin. Pharmokinet. 22:1-10.
Ulmer et al, 1993 Curr. Opinion. Invest. Drugs 2:983-989.
Chang et al, 1978 Nature 275:617-624.
Goeddel et al 1980 Nucl. Acid. Res. 8:4057-4074.
Harkness et al, 1992 J. Bacteriol. 174:2425-2430.
Loeb M.R., 1987 Infec. Immun. 55:2612-2618.
Holmes and Quigley 1981. Analyt. Biochem. 114:193-197.
Young and Davis, 1983 Proc. Natl. Acad. Sci. USA 80: 1194-1196.
Panezutti et al, 1993 Infec. Immun. 61:1867-1872.
Lipinska et al, 1985 Bacteriol. 171:1574-1584.
Barenkamp et al, 1986 Infect. Immun. 52:572-578.
Crowl et al, 1985 Gene 38:31-38.
Klein Michel H.
Loosmore Sheena M.
Oomen Raymond P.
Connaught Laboratories Limited
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