.alpha.-ACETYLENIC DERIVATIVES OF AMINES

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260558A, 260558S, 260559T, 260559A, 260561R, 260561A, 260561S, 260561N, 260564A, 1605705S, 260583FF, 536 26, 560 24, 560 33, 560157, 560159, 560165, 424244, 424300, 424316, 424320, 424325, 424330, C07C 8724, C07C 6902, C07C10310, C01B 2526

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041395638

ABSTRACT:
Novel acetylenic derivatives of amines of the following general structure: ##STR1## WHEREIN Z is .beta.-methylthioethyl, .beta.-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, .gamma.-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3 AND R.sub.1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sub.1 is other than hydrogen, n is 2; and each of R.sub.a and R.sub.b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR3## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; with the provisos that when Z is .beta.-benzylthioethyl or S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, R.sub.b is hydrogen, and when Z is ##STR4## EACH OF R.sub.a and R.sub.b can be the same or different; and pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
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Mavrov et al., "Index Chemicus", vol. 30, #93265 (1968).
SIFA, "French Patents Abstracts", vol. 6, No. 47, p. 3:7 (1966).
Dumont et al., "Chem. Ab.", Ab. No. 66:115254r (1967).

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