Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
260558A, 260558S, 260559T, 260559A, 260561R, 260561A, 260561S, 260561N, 260564A, 1605705S, 260583FF, 536 26, 560 24, 560 33, 560157, 560159, 560165, 424244, 424300, 424316, 424320, 424325, 424330, C07C 8724, C07C 6902, C07C10310, C01B 2526
Novel acetylenic derivatives of amines of the following general structure: ##STR1## WHEREIN Z is .beta.-methylthioethyl, .beta.-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, .gamma.-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3 AND R.sub.1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sub.1 is other than hydrogen, n is 2; and each of R.sub.a and R.sub.b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR3## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; with the provisos that when Z is .beta.-benzylthioethyl or S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, R.sub.b is hydrogen, and when Z is ##STR4## EACH OF R.sub.a and R.sub.b can be the same or different; and pharmaceutically acceptable salts and individual optical isomers thereof.
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Metcalf Brian W.
Douglas Winston A.
Hattan L. Ruth
Merrell Toraude et Compagnie
Rauchfuss, Jr. George W.
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