A-40104 antibiotics and process for production thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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195 81, 560179, 560185, C07G 1100

Patent

active

041297210

ABSTRACT:
A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.

REFERENCES:
patent: 3949079 (1976-04-01), Brandi et al.
Egger, J. Antibiotics, 29, 923-927 (1976).

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