Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
536 235, 536 2431, 435 6, 435 721, 435 723, 4353201, C07H 2104, C12N 1500
The 3' untranslated region of the human prohibitin gene has been isolated for use in a cancer susceptibility screen and as a therapeutic agent for the treatment of cancer.
patent: 5401635 (1995-03-01), Nakamura et al.
McClung J K; King R L; Walker L S; Danner D B; Nuell M J; Stewart C A; Dell'Orco R T. Expression of prohibitin, an antiproliferative protein. Experimental Gerontology, (Jul.-Aug. 1992) 27 (4) 413-7.
Asamoto, M. and Cohen, S.M., "Prohibitin gene is overexpressed but not mutated in rat bladder carcinomas and cell lines," Cancer Let 83:201-207 (1994).
Black, D. and Solomon, E., "The search for the familial breast/ovarian cancer gene," Trends in Genetics 9:22-26 (1993).
Black, et al., "A somatic cell hybrid map of the long arm of human chromosome 17, containing the familial breast cancer locus (BRCAI)," Am J Hum Genet 52:702-710 (1993).
Castilla, et al., "Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer," Nature Genetics 8:387-391 (1993).
Cliby, et al., "Absence of prohibitin gene mutations in human epithelial ovarian tumors," Gynecologic Oncology 50:34-37 (1993).
Deisseroth, et al., "Genetic therapy of human neoplastic disease," Proc Am Assoc Cancer Res 36:655-656 (1995).
Gross-Bellard, et al., "Isolation of high-molecular-weight DNA from mammalian cells," Eur J Biochem 36:32.
Holmes D.S. and Quigley, M., "A rpaid boiling method for the preparation of bacterial plasmids," Anal Biochem 114:193-197 (1981).
Hongyo, et al., "`Cold SSCP`:a simple, rapid and nonradioactive method for optimized single-strand conformation polymorphism analyses," Nuc Acids Res 21:3637-3642 (1993).
Jupe, et al., "Lack of heterozygosity for prohibitin in breast cancer cell lines," Proc Am Assoc Cancer Res 36:569 (abstract 3390) (1995).
Jupe, et al., "Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines," Exp Cell Res 218:577-580 (1995).
Liu, et al., "Prohibitin expression during cellular senescence of human diploid fibroblasts," Biochem Biophys Res Comm 201:409-414 (1994).
McClung, et al., "Isolation of a cDNA hybrid selects antiproliferative mRNA from rat liver," Biochem Biophys Res Comm 164:1316-1322 (1989).
Nuell, et al., "Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells," Mol Cell Biol 11:1372-1381 (1991).
Saiki, et al., "Enzymatic amplification of .beta.-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia," Science 230:1350-1354 (1985).
Sato, et al., "The human prohibitin (PHB) gene family and its somatic mutations inhuman tumors," Genomics 17:762-764 (1993).
Sato, et al., "The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer," Cancer Res 52:1643-1646 (1992).
Suggs, et al., "Use of synthetic oligonucleotides as hybridization probles: isolation of cloned cDNA sequences for human .beta..sub.2 -microglobulin." Proc Natl Acad Sci 78:6613-6617 (1981).
Tokino, et al., "Absence of germline prohibitin mutations in early onset breast cancer," International J Oncology 3:769-772 (1993).
White, et al., "Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism," Genomics 11:228-230 (1991).
Rastinejad et al. Cell vol. 75, pp. 1107-1117. Tumor Suppression by RNA from the 3' Untranslated Region of alpha-tropomyosin, Dec. 17, 1993.
Hillier et al. Gen Bank Accession No. R60946, National Center for Biotechnology Information, Bethesda, MD, May 24, 1995.
Orkin et al., Dec. 7, 1995, "Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy", issued by the National Institutes of Health.
Choongkittaworn N M; Kim K H; Danner D B; Griswold M D. Expression of prohibitin in rat seminiferous epithelium. Biology of Reproduction, (Aug. 1993) 49 (2) 300-10.
Terashima M; Kim K M; Adachi T; Nielsen P J; Reth M; Kohler G; Lamers M C. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO Journal, (Aug. 15, 1994) 13 (16) 3782-92.
Dell'Orco, Sr. Robert Thomas
MClung J. Keith
Oklahoma Medical Research Foundation
Romeo David S.
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