3' untranslated region of the human prohibitin gene

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives


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536 235, 536 2431, 435 6, 435 721, 435 723, 4353201, C07H 2104, C12N 1500




The 3' untranslated region of the human prohibitin gene has been isolated for use in a cancer susceptibility screen and as a therapeutic agent for the treatment of cancer.

patent: 5401635 (1995-03-01), Nakamura et al.
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Castilla, et al., "Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer," Nature Genetics 8:387-391 (1993).
Cliby, et al., "Absence of prohibitin gene mutations in human epithelial ovarian tumors," Gynecologic Oncology 50:34-37 (1993).
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Hongyo, et al., "`Cold SSCP`:a simple, rapid and nonradioactive method for optimized single-strand conformation polymorphism analyses," Nuc Acids Res 21:3637-3642 (1993).
Jupe, et al., "Lack of heterozygosity for prohibitin in breast cancer cell lines," Proc Am Assoc Cancer Res 36:569 (abstract 3390) (1995).
Jupe, et al., "Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines," Exp Cell Res 218:577-580 (1995).
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McClung, et al., "Isolation of a cDNA hybrid selects antiproliferative mRNA from rat liver," Biochem Biophys Res Comm 164:1316-1322 (1989).
Nuell, et al., "Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells," Mol Cell Biol 11:1372-1381 (1991).
Saiki, et al., "Enzymatic amplification of .beta.-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia," Science 230:1350-1354 (1985).
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Sato, et al., "The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer," Cancer Res 52:1643-1646 (1992).
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Tokino, et al., "Absence of germline prohibitin mutations in early onset breast cancer," International J Oncology 3:769-772 (1993).
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Choongkittaworn N M; Kim K H; Danner D B; Griswold M D. Expression of prohibitin in rat seminiferous epithelium. Biology of Reproduction, (Aug. 1993) 49 (2) 300-10.
Terashima M; Kim K M; Adachi T; Nielsen P J; Reth M; Kohler G; Lamers M C. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO Journal, (Aug. 15, 1994) 13 (16) 3782-92.


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