Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
260239A, 2602452T, 2602453, 424258, 424263, 424269, 424270, 424272, 424273B, 424274, 542413, 542443, C07D48704
Disclosed are 3- and 6-substituted 7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein R.sup.6, R.sup.7 and R.sup.8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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Christensen Burton G.
Johnston David B. R.
Schmitt Susan M.
Arno James A.
Lee Mary C.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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