2′-Substituted RNA preparation

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S022100, C536S023100, C536S025300, C536S027100, C536S027110

Reexamination Certificate



A process for the preparation of a compound of formula (1):is provided, which comprises the reaction a compound of formula (2):with a compound of formula Al(OR)3under substantially anhydrous conditions. X, and X1are each independently H or a protecting group, B is a base; R is an alkyl, alkoxyalkyl, alkenyl or alkynyl group, each of which may be optionally substituted, and L is a leaving group.

patent: WO 9535102 (1995-12-01), None
patent: WO 9627606 (1996-09-01), None
McGee D P C et al: “Reaction of Anhydronucleosides with Magnesium Alkoxides: Regiospecific Synthesis of 2′-0-Alkylpyrimidine Nucleosides” Nucleosides & Nucleotides, US, Marcel Dekker, Inc., vol. 15, No. 11/12, Jan. 1, 1996, pp. 1797-1803, XP002066801 ISSN: 0732-8311 abstract.
B.S. Ross et al.: “A Novel and Economical Synthesis of 2′-0-Alkyl-Uridines.” Nucleosides & Nucleotides., vol. 16, No. 7-9, 1997, pp. 1641-1643, XP002137095 Marcel Dekker, Inc., US, ISSN: 0732-8311 the whole document.


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