Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S024300, C536S025300, C536S026600, C536S004100, C435S006120

Reexamination Certificate



Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.

patent: 5684143 (1997-11-01), Gryaznov et al.
patent: WO 9110671 (1991-07-01), None
Gryaznov et al.,Nucleic Acids Res., 24 (8):1508-1514 (1996).
Ikeda et al.,Nucleic Acids Res., 26(9):2237-2244 (1998).
Kawasaki et at.,J. Med. Chem., 36:831-841 (1993).
Schultz and Gryaznov,Nucleic Acids Res., 24(15):2966-2973 (1996).
Skorski et al.,PNAS, 94:3966-3971 (1997).
International Search Report for PCT/US01/01918, Geron Corporation, May 29, 2001.


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