2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Details

C514S263400, C544S244000, C544S276000, C544S277000

Reexamination Certificate

active

10942314

ABSTRACT:
Compounds which are active against viruses have the following Formulas:wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3;R1is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl;R2is selected from the group consisting of C2-18alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; andR3is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.

REFERENCES:
patent: 6352991 (2002-03-01), Zemlicka et al.
patent: 2005/0113393 (2005-05-01), Zemlicka et al.
Kumar, Current Medicinal Chemistry, vol. 11, No. 20, Oct. 2004, pp. 2749-2766(18).
Chen, J. Med. Chem 46, 1531 (2003).
Zemlicka, Frontiers in Nucleosides and Nucleic Acids (Schinazi and Liotta, eds.) (IHL Press 2004), 267-307.

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