14-Amino derivatives of morphine, methods of making them and ana

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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546 44, 546 45, 542403, A61K 31485, C07D48906

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active

042410673

ABSTRACT:
Novel derivatives of morphine having the general formula: ##STR1## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are certain specified values, and their pharmaceutically acceptable salts.
The compounds exhibit activity in the central nervous system and may be presented in the form of pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable diluent or carrier.

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Allen et al., Chemical Communications, (1970), p. 1346.
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Allen; R. M., "Synthesis of New Codeinone and Indolinocodeinone Derivatives", Thesis submitted to Loughborough University of Technology, 9/71, cited in Index to Theses, vol. XXII, 1971-1972, ed Paterson et al., Aslib, London (1974).
Rice, Journal of Medicinal Chemistry, vol. 20, No. 1, pp. 164-165, (1/77).

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