1(2H)-Isoquinolone compounds and acid addition salts thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...


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42424854, 42424855, 42424856, 424250, 424258, 544128, 544363, C07D21714, A61K 3147




1(2H)-Isoquinolone compounds represented by the formula (1) ##STR1## wherein Y represents hydrogen, chlorine or a methoxy group, Z represents a straight chain or branched chain divalent saturated aliphatic hydrocarbon group having 2 to 4 carbon atoms, R.sub.1 represents a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, an N-substituted carbamoyl group, a phenyl group or a substituted phenyl group, R.sub.2 represents hydrogen or a lower alkyl group, and R.sub.3 represents a lower alkyl group, or R.sub.2 and R.sub.3 can form, when taken together with the nitrogen atom to which they are attached, a heterocyclic group, and the acid addition salts thereof, useful as analgesic, gastric secretion inhibitory, anti-depression, anti-histamine, anti-cholinergic and anti-ulcer agents.

patent: 3600394 (1971-08-01), Coyne et al.
patent: 4137318 (1979-01-01), Eberlein et al.


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