0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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C07D26534

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active

040668320

ABSTRACT:
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1##

REFERENCES:
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Lowe, et al., J. Chem. Soc. Perkins I, 1321-1328 (1973).
Luttringer et al., Tetrahedron Letters, 4163-4166 (1973).
Sheehan et al., J. Heterocycl. Chem., 5, 779-783 (1968).
Mukerjee et al., Synthesis, 327-346 (1973).

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